Journal of the National Cancer Institute, 103(15), 1179-1189.Ĥ- Ding, J., Warren, R., Girling, A., Thompson, D., & Easton, D. Mammographic breast density and subsequent risk of breast cancer in postmenopausal women according to tumor characteristics. Cancer epidemiology, biomarkers & prevention, 18(2), 479-485.ģ- Yaghjyan, L., Colditz, G. Is there a difference in the association between percent mammographic density and subtypes of breast cancer? Luminal A and triple-negative breast cancer. The Association of Mammographic Density and Molecular Breast Cancer SubtypeMammographic Density and Breast Cancer Subtype. Volkan aslan MD, Ozan yazıcı MD, Ahmet özet MD.ġ- Edwards, B. This well-designed study, which seems to have significant contributions to oncology practice, could provide valuable insights into existing breast cancer risk prediction models if subgroup analyses are conducted. In conclusion, Shu Jiang and colleagues found in their study that the rate of change in breast density was associated with the risk of subsequent breast cancer, but the pattern of density change was not analyzed in subgroups based on breast cancer subtypes and stages. The further analysis of the association of breast cancer subgourps and results of the study presented by Shu Jiang for that issue will shed on light on conflicting data in literature, In literature there has been conflicting data regarding the association in between breast density and subsequent breast cancer pathological subtypes. reported that mammographic density percentage may be more strongly associated with ER-positive breast cancer than ER-negative breast cancer (4). A study conducted on postmenopausal patients found that higher mammographic density was associated with more aggressive tumor characteristics and in situ tumors (3). Another study showed that mammographic density percentage was positively associated with both Luminal A and triple-negative breast cancer (2). In one study, increased breast density was found to be more strongly associated with HER2-positive tumors compared to Luminal A breast cancer (1). Several studies have investigated the association between changes in mammographic density and the risk of developing breast cancer according to breast cancer subtypes. The potential differential impact of breast density on the risk of specific pathological subtypes of breast cancer is still under evaluation. However, no analysis was performed based on breast cancer subtypes, tumor characteristics, and stages in patients who were diagnosed with breast cancer during follow-up.Ĭharacterizing the relationship between breast density and breast cancer subtypes and disease stage can help us understand how breast density affects the risk of breast cancer, as well as how breast cancer subtypes differ in etiology. This prospective cohort study, which measured changes in breast density volumetrically for the first time, analyzed each breast separately, providing a finding that will guide personalized screening and prevention approaches that are important for oncology practice. Shu Jiang and colleagues found in their study that the rate of change in breast density is associated with the risk of subsequent breast cancer. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.Illustration for Change in MD Stratified by a) BI-RADS A (MD 15.5% Bottom Row) for the Case Breast in the Case Women and Control Women Over Time Volumetric Cut Points for the Original Scale MD to BI-RADS LevelsĮFigure 5. Scatter Plot of Box-Cox Transformation vs Original Scale Mammographic DensityĮFigure 4. Three Types of Correlations Using Box-Cox–Transformed Breast Densities in the Control Women: R 1 = Correlation Within the Same Breast Over Time R 2 = Inter-breast Correlation Within the Same Woman R 3 = Cross-Correlation Between Breasts at Different Time PointsĮFigure 3. Top Row Shows Histogram of Mammographic Density of the Two Breasts on the Original Volumetric Scale and the Corresponding QQ Plot for the Normality of Residuals Bottom Row Shows Mammographic Density on the Box-Cox–Transformed Scale and the Corresponding QQ Plot for the Normality of Residuals With Improved FitĮFigure 2.
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